Prognostic blood biomarkers in lymphoma: the impact of new anti-tumor drugs
Title / Acronym : BIO-FLIRT
Objective : To compare the efficacy of two routes of rituximab infusion (subcutaneous vs intraveinous) in patients with previously untreated low-burden follicular lymphoma.
Principal investigators : Guillaume CARTRON (CHRU Montpellier, France), Delphine PRANGER (Hospital of Charleroi, Belgium)
Funding : LYSARC / Roche Laboratory
Duration : 5.5 years
Other information : French multicentre phase III trial for which all patients are immunomonitored in Rennes
Title / Acronym : BIO-GALEN
Objective : For phase Ib, determine the recommended dose of lenalidomide to be used in combination with obinutuzumab. For Phase II, evaluate the efficacy of this combination therapy in patients with follicular lymphoma or diffuse large cell lymphoma
Principal Investigators : Franck Morschhauser (CHRU Lille, France), Roch Houot (CHU Rennes, France)
Funding : LYSARC / Roche and Celgene Laboratories
Duration : 10 years
Other information : Phase Ib / II trial for which all patients are immunomonitored in Rennes
Title / Acronym : BIO-NIVEAU
Objective : To evaluate the gain in clinical response provided by the addition of nivolumab to Gemcitabine / Oxaliplatin / Rituximab in elderly patients or who are not eligible for high-dose chemotherapy and relapsing from non-Hodgkin's lymphoma.
Principal investigators : Gerald Held (Germany)
Funding : BMS laboratory
Duration :
Other information : European multicenter phase II / III trial for which French and German patients are immunomonitored at the SITI laboratory
Immunosuppressive properties of mesenchymal stem cells: mechanisms and clinical applications
Title / Acronym : FATSCAR
Objective : To evaluate the efficacy of adipose tissue autograft on the repair of recurring ulcer
Principal Investigators : Cécile Méal, Nicolas Bertheuil (CHU Rennes, France)
Funding : CHU Rennes
Duration : 1 year
Other information :
Title / Acronym : Mechanical-SVF
Objective : Characterization of stromal vascular fraction (SVF) derived from adipose tissue obtained by mechanical dissociation versus enzymatic digestion
Principal investigators : Nicolas Bertheuil (CHU Rennes, France)
Funding : CHU Rennes
Duration : 1 year
Other information : Study carried out on 15 subjects
Title / Acronym : ADIPOA-2
Objective : To ensure the safety and tolerance of the treatment of osteoarthritis by injection of adipocyte stem cells into the knee joint
Principal Investigators : Christian Jorgensen (CHU Montpellier, France)
Funding : European Union
Duration : 2 years
Other information : partnership with clinical centers from 6 countries (France, Ireland, Italy, Germany, the Netherlands, United Kingdom) with immunomonitoring of the French, Italian and German patients performed in 2 sites (SITI/Rennes and Montpellier)
Title / Acronym : Scleroderma
Objective : To analyze the immunomodulatory and anti-fibrotic effects of bone marrow-derived allogeneic mesenchymal stem cell (MSC) injection by analyzing systemic and cutaneous responses in patients with systemic scleroderma.
Principal Investigators : Dominique Farge
Funding : Assistance Publique-Hôpitaux de Paris / consortium eCellFrance
Duration :
Other information : Phase I-II trial in one center (Paris) for 12 patients immuno-monitored in Rennes at the SITI laboratory
Suppressive myeloid cells and sepsis
Title / Acronym : Imprim
Objective : To study immunodeficiency biomarkers in all ICU patients, comparing non-septic patients to septic patients.
Principal Investigators : Fabrice UHEL (CHU Rennes, France)
Funding : CHU Rennes
Duration : 24 months
Other information : Single center study
Title / Acronym : Randomized L-Citrulline Immunonutrition Trial in Medical Resuscitation / Immunocitre
Objective : To study the effects of citrulline administration on immune dysfunction acquired during resuscitation. The main objective is to test whether L-citrulline decreases the rate of organ failure at Day 7 in patients from ICU presenting with hypo-arginine on admission.
Principal investigators : Jean-Marc Tadié (CHU Rennes, France)
Funding : Programme Hospitalier de Recherche Clinique 2014
Duration : 24 months
Other information :
Title / Acronym : Immunological and bacteriological approaches of the development of postoperative mediastinitis due to Staphylococcus aureus / Mediastaph
Objective : To address the link between plasma activity of the Indoleamine 2,3-dioxygenase enzyme (IDO) and hypo-reactivity of neutrophils (PNN) and macrophages during exposure to Methicillin-sensitive Staphylococcus aureus (SAMS).
Principal investigators : Jean-Marc Tadié
Funding : 2014-2016 Foundation pour l’Avenir
Duration : 24 months
Other information : Single center
Title / Acronym : Study of the effects of bronchoalveolar lavage fluids from ARDS patients on the functionality of neutrophils / BALARDS
Objective : i) To measure the effect of BAL fluids from ARDS patients on neutrophils apoptosis, ii) To measure the effect of BAL fluids on apoptotic neutrophils efferocytosis by macrophages.
Principal investigators : Jean-Marc Tadié
Funding : CHU Rennes
Duration : 24 months
Other information : Single center
Title / Acronym : Beneficial effects of maintaining mechanical ventilation during cardiopulmonary bypass (CPB) for cardiac surgery on postoperative infections/ VECAR
Objective : to address the effect of the maintenance of mechanical ventilation during CPB on the frequency of postoperative infections.
Principal investigators : Jean-Marc Tadié
Funding : Programme Hospitalier de Recherche Clinique national
Duration : 24 months
Other information : Multicenter study. 1400 patients including 500 patients with immunomonitoring performed in SITI/Rennes
